Blar i forfatter "Myles, Rachel"

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    • Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? 

      Dietrichs, Erik Sveberg; Myles, Rachel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-27)
      Hypothermia was increasingly proposed as a neuroprotective therapy in the 1990s, culminating in the publication of two randomized trials in 2002, which showed beneficial effects of therapeutic hypothermia in comatose survivors of cardiac arrest.1,2 Therapeutic hypothermia was subsequently included in guidelines for the treatment of this patient group. However, doubt as to whether hypothermia provided ...

    • Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology 

      Dietrichs, Erik Sveberg; McGlynn, Karen; Allan, Andrew; Connolly, Adam; Bishop, Martin; Burton, Francis; Kettlewell, Sarah; Myles, Rachel; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-07)
      <i>Aims</i> - Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This <i>in vitro</i> experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Methods and results</i> - Detailed ECG, surface electrogram, and panoramic optical ...

    • A novel ECG-biomarker for cardiac arrest during hypothermia 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Myles, Rachel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-10)
      <i>Background</i> - Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Main body</i> - Evaluation of ECG-data from accidental and therapeutic hypothermia patients and experimental data on ECG ...